Endotoxin differentially modulates the basolateral and apical sodium/proton exchangers (NHE) in enterocytes


CETIN S., DUNKLEBARGER J., LI J., BOYLE P., Ergun O. , QURESHI F., ...Daha Fazla

SURGERY, cilt.136, ss.375-383, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 136 Konu: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.surg.2004.05.013
  • Dergi Adı: SURGERY
  • Sayfa Sayıları: ss.375-383

Özet

Background. Maintenance of enterocyte activity during extracellular acidosis requires functional sodium/proton exchangers (NHE), which are present at both basolateral and apical surfaces. Necrotizing enterocolitis is characterized by systemic hypoperfusion, metabolic acidosis, and the apical to basolateral translocation of endotoxin (lipopolysaccharide [LPS]). We hypothesized that LPS differentially impairs NHE activity at the basolateral or apical domains of enterocytes, leading to cellular acidification, and explored the mechanisms involved.