The effect of tomatine on metastasis related matrix metalloproteinase (MMP) activities in breast cancer cell model


YELKEN B. O. , Balci T., SUSLUER S. Y. , KAYABASI C., AVCI C. B. , Kirmizibayrak P. B. , ...More

GENE, vol.627, pp.408-411, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 627
  • Publication Date: 2017
  • Doi Number: 10.1016/j.gene.2017.06.054
  • Title of Journal : GENE
  • Page Numbers: pp.408-411
  • Keywords: Breast cancer, Matrix metalloproteinase, Tomatine, ALPHA-TOMATINE, IV COLLAGENASE, GLYCOALKALOIDS, EXPRESSION, INVASION, MATRIX-METALLOPROTEINASE-9, PROGRESSION, INHIBITORS, APOPTOSIS, TISSUES

Abstract

Breast cancer is one of the most common malignancies in women and metastasis is the cause of morbidity and mortality in patients. In the development of metastasis, the matrix metalloproteinase (MMP) family has a very important role in tumor development. MMP-2 and MMP-9 work together for extracellular matrix (ECM) cleavage to increase migration. Tomatine is a secondary metabolite that has a natural defense role against plants, fungi, viruses and bacteria that are synthesized from tomato. In addition, tomatine is also known that it breaks down the cell membrane and is a strong inhibitor in human cancer cells. In this study, it was aimed to evaluate the effect of tomatine on cytotoxicity, apoptosis and matrix metalloproteinase inhibition in MCF-7 cell lines.