In-vitro activity of rifabutin against rifampicin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations


Cavusoglu C. , KARACA-DERICI Y., BILGIC A.

CLINICAL MICROBIOLOGY AND INFECTION, cilt.10, ss.662-665, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 10 Konu: 7
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1469-0691.2004.00917.x
  • Dergi Adı: CLINICAL MICROBIOLOGY AND INFECTION
  • Sayfa Sayıları: ss.662-665

Özet

The relationship between resistance to rifampicin and rifabutin and genetic alterations in the rpoB gene of 41 rifampicin-resistant isolates of Mycobacterium tuberculosis was evaluated. Although 35 isolates with rifampicin MICs greater than or equal to 32 mg/L were also rifabutin-resistant, six isolates with rifampicin MICs of 2-16 mg/L were susceptible to rifabutin (MIC less than or equal to 0.5 mg/L). Mutations Asp516Val, Asp516Tyr, Leu533Pro and the double mutation Met515Ile and Leu533Pro influenced susceptibility to rifampicin, but not to rifabutin. All mutations at codons 531 and 526, except one isolate with a His526Cys mutation, correlated with resistance to both compounds.