The aim of the present study was to develop a novel Flurbiprofen (FLB) loaded nanostructured lipid carrier (NLC) based alginate inserts for treatment of ocular inflammation. 0.3% FLB loaded NLCs were prepared by means of high shear homogenization and afterwards 0.75% sodium alginate was added into these NLCs. Glycerin or PEG 400 at 5% concentration was added to NLCs as plasticizers and by using solvent casting evaporation technique, inserts were developed. Inserts were evaluated for diameter, thickness, weight uniformity, drug content, moisture absorption and moisture loss. Also in vitro release and stability studies were performed. The characterization properties of inserts were acceptable for ophthalmic application. The inserts developed with the addition of glycerin (Ins1(FLB)) were found as optimum formulation for FLB in vitro release. FLB loaded NLC based inserts developed with sodium alginate and glycerin may be offered as appropriate vehicles for ocular delivery.