Regulation of Epigenetic Modifiers Including KDM6B, by Interferon-gamma and Interleukin-4 in Human Macrophages

Yildirim-Buharalioglu G. , Bond M., Sala-Newby G. B. , Hindmarch C. C. T. , Newby A. C.

FRONTIERS IN IMMUNOLOGY, vol.8, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8
  • Publication Date: 2017
  • Doi Number: 10.3389/fimmu.2017.00092
  • Title of Journal : FRONTIERS IN IMMUNOLOGY
  • Keywords: macrophage phenotype, epigenetics, interferon-gamma, interleukin-4, proliferation, WOLF-HIRSCHHORN-SYNDROME, HISTONE METHYLTRANSFERASE SMYD3, SISTER-CHROMATID COHESION, AURORA-B KINASE, GENE-EXPRESSION, CELL-CYCLE, IN-VITRO, TRANSCRIPTIONAL ACTIVATION, CHROMOSOME CONDENSATION, ALTERNATIVE ACTIVATION

Abstract

Background: Interferon-gamma (IFN-gamma) or interleukin-4 (IL-4) drives widely different transcriptional programs in macrophages. However, how IFN-gamma and IL-4 alter expression of histone-modifying enzymes involved in epigenetic regulation and how this affects the resulting phenotypic polarization is incompletely understood.