FRONTIERS IN IMMUNOLOGY, vol.8, 2017 (Journal Indexed in SCI)
Article / Article
Title of Journal :
FRONTIERS IN IMMUNOLOGY
macrophage phenotype, epigenetics, interferon-gamma, interleukin-4, proliferation, WOLF-HIRSCHHORN-SYNDROME, HISTONE METHYLTRANSFERASE SMYD3, SISTER-CHROMATID COHESION, AURORA-B KINASE, GENE-EXPRESSION, CELL-CYCLE, IN-VITRO, TRANSCRIPTIONAL ACTIVATION, CHROMOSOME CONDENSATION, ALTERNATIVE ACTIVATION
Background: Interferon-gamma (IFN-gamma) or interleukin-4 (IL-4) drives widely different transcriptional programs in macrophages. However, how IFN-gamma and IL-4 alter expression of histone-modifying enzymes involved in epigenetic regulation and how this affects the resulting phenotypic polarization is incompletely understood.