Investigation of in vitro efficiency of magnetic nanoparticle-conjugated I-125-uracil glucuronides in adenocarcinoma cells


MEDİNE E. İ. , ÜNAK P. , Sakarya S., Ozkaya F.

JOURNAL OF NANOPARTICLE RESEARCH, cilt.13, ss.4703-4715, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 13 Konu: 10
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s11051-011-0436-6
  • Dergi Adı: JOURNAL OF NANOPARTICLE RESEARCH
  • Sayfa Sayıları: ss.4703-4715

Özet

Modification of the magnetic properties of a drug can be used to direct the drug to the desired site, enhancing its therapeutic effectiveness and reducing side effects. In this study, surface-modified magnetic nanoparticles were immobilized with uracil glucuronide derivatives and then labeled with I-125. The morphology, structure, and composition of the magnetic particles were examined by TEM, SEM, VSM, and XRD. The particles sizes were about 50 nm. The labeling yield was 93.8% for uracil-O-glucuronide-immobilized magnetic particles and 95.0% for uracil-N-glucuronide-immobilized magnetic particles. The cell incorporation rates of N- and O-glucuronides were higher than those of uracil. The incorporation rates of uracil-, O-glucuronide-, and N-glucuronide-conjugated magnetic particles were all high. The cell incorporation rates of ligand-conjugated magnetic particles increased under a magnetic field.