Investigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive I-131 in the cancer cell lines


Uzaras C., Avcibasi U., Demiroglu H., MEDİNE E. İ. , Kilcar A. , Muftuler F. Z. B. , et al.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.307, ss.131-140, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 307 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10967-015-4119-0
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayısı: ss.131-140

Özet

The aim of this study is to determine the incorporations of PHT radiolabeled with I-131 (I-131-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of I-131-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of I-131, I-131-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of (IPHT)-I-131 on the three cell lines decreased with increasing radioactivity. Consequently, I-131-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors.