Preparation, quality control and stability of Tc-99m-cefuroxime axetil


Lambrecht F. , DURKAN K. , ÜNAK P.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.275, ss.161-164, 2008 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 275 Konu: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s10967-007-6999-0
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayıları: ss.161-164

Özet

Cefuroxime axetil, a cephalosporin antibiotic used to treat bacterial infections, was investigated to label with Tc-99m. Radiolabeling of cefuroxime axetil was carried out by using stannous chloride method. Effects of pH and stannous chloride amount on the radiolabeling yield were investigated. The radiochemical purity of Tc-99m-cefuroxime axetil was determined by thin layer radio chromatography (TLRC), electrophoresis and high performance liquid chromatography. The maximum radiolabeling yield was 98 +/- 1%.