Preparation, quality control and stability of Tc-99m-cefuroxime axetil


Lambrecht F. , DURKAN K. , ÜNAK P.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol.275, no.1, pp.161-164, 2008 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 275 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1007/s10967-007-6999-0
  • Title of Journal : JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Page Numbers: pp.161-164

Abstract

Cefuroxime axetil, a cephalosporin antibiotic used to treat bacterial infections, was investigated to label with Tc-99m. Radiolabeling of cefuroxime axetil was carried out by using stannous chloride method. Effects of pH and stannous chloride amount on the radiolabeling yield were investigated. The radiochemical purity of Tc-99m-cefuroxime axetil was determined by thin layer radio chromatography (TLRC), electrophoresis and high performance liquid chromatography. The maximum radiolabeling yield was 98 +/- 1%.