Synthesis of Stable Acyclic Aminals Derived from L-(+)-Aspartic Acid and Their Application in Asymmetric Henry Reactions


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Koz G., ASTLEY D. , ASTLEY S. T.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, cilt.68, ss.57-63, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 68 Konu: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5560/znb.2013-2228
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
  • Sayfa Sayıları: ss.57-63

Özet

A series of stable acyclic aminals derived from L-(+)-aspartic acid were synthesized in excellent yields (up to 96%) and characterized by spectroscopic methods. They were applied as enantioselective catalysts in Henry reactions of nitromethane with various aldehydes in the presence of Cu(II) ions, affording the corresponding adducts in high yields (up to 90%) and enantioselectivities (up to 92% ee).