Methylprednisolone induces apoptosis by interacting with the JAK/STAT pathway in HL-60 and K-562 leukemic cells


Kaymaz B. , SELVİ N., SAYDAM G. , ŞAHİN F. , KOSOVA B.

HEMATOLOGY, cilt.17, ss.93-99, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Objective: To determine the gene expression profiles of the JAK/STAT pathway members STAT3, STAT5A, STAT5B at both mRNA and protein levels in HL-60 and K-562 leukemia cells that were undergoing apoptosis following high-dose methylprednisolone (MP) treatment.