Granulomatous disease in common variable immunodeficiency


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Ardeniz O. , cunningham-rundles C.

CLINICAL IMMUNOLOGY, cilt.133, ss.198-207, 2009 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 133 Konu: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.clim.2009.05.001
  • Dergi Adı: CLINICAL IMMUNOLOGY
  • Sayfa Sayısı: ss.198-207

Özet

Granulomatous disease occurs in 8-22% of patients with common variable immunodeficiency (CVID). We examined the clinical and immunologic information of all 37 of 455 (8.1%) CVID subjects with this complication. The median age at diagnosis of CVID was 26 (2-59). 14 had granulomas 1-18 years before diagnosis of CVID. In 6 detection of granulomas coincided with this diagnosis; for 17, granulomas were documented later. 54% had lung granulomas, 43% in lymph nodes and 32% in liver. 54% of the group had had autoimmune diseases, mostly immune thrombocytopenia and hemolytic anemia. 24% had had a splenectomy. Nineteen (51.3%) required steroid treatment for granulomas; other immune suppressants were used in some. Over 25 years 28.5% died (median age 37.5), but not significantly more when compared to our CVID patients without granulomas (19.8%). Those with lung granulomas had similar mortality to those with granulomas in other tissues. (C) 2009 Elsevier Inc. All rights reserved.