Introduction: The purpose of this study was to investigate the effect of antioxidant treatment and delayed bonding on the shear bond strength of metal brackets bonded with composite resin to human enamel after bleaching with carbamide peroxide (CP). Methods: Eighty recently extracted premolars were divided into an experimental group (n = 60), which was bleached with 10% CP, and a control group (n = 20), which was not bleached. The experimental group was further divided into 3 groups. Specimens in group 1 (n = 20) were bonded immediately after bleaching; specimens in group 2 (n = 20) were bleached, then treated with 10% sodium ascorbate, an antioxidant agent, and then bonded; group 3 specimens (n = 20) were bleached, then immersed in artificial saliva and held for 1 week before bonding. The specimens were debonded, and the enamel surfaces and bracket bases were examined with a stereomicroscope. The adhesive remnant index was used to assess the amount of resin left on the enamel surfaces after debonding. The shear bond strength data were subjected to 1-way analysis of variance. Multiple comparisons were performed with the Bonferroni test. The level of significance was established at P < .05 for all statistical tests. Results: Shear bond strength of brackets bonded immediately after bleaching with 10% CP was significantly lower than that of brackets bonded to unbleached enamel (P < .05). No statistically significant differences in shear bond strength were noted when the antioxidant-treated and delayed bonding groups were compared with the control group (P > .05). Conclusions: Bleaching with 10% CP immediately before bonding reduces the bond strength of composite resin to enamel. Treating the bleached enamel surface with 10% sodium ascorbate or waiting 1 week reverses the reduction.