The Mediterranean fishery and aquaculture industry is looking for alternative species to culture in sea cages. Different kinds of species can be chosen as a potential aquaculture candidate because of their eating qualities, their nature and ability to be held in captivity at high densities. In this regard, brown meagre (Sciaena umbra) is one of the candidate species, which offers good possibilities. No studies about the fish quality of this species exist, neither for wild nor for cultured fishes. In the current study, the proximate and fatty acid composition of the flesh of cultured and wild brown meagre (Sciaena umbra) were evaluated monthly during 8 months. Major quality parameters, such as muscle composition, fat deposition, muscle fatty acid composition and sensorial quality were studied in wild and cultured brown meagre. Lipid content of cultured meagre was much higher than that of wild fish. Differences were also observed in fatty acid profiles. Cultured fish were characterized by higher levels of monoenes, and wild fish by higher levels of saturates and n-3/n-6 ratios. Differences were also noted in the sensorial appearance of fish.