This study aims to achieve high comfort characteristics in medical corsets. For this aim, initially the expectations of users were determined by a survey and special yarns have been selected according to the survey responses. Then, different corset fabrics have been designed in a functional structure. Later, the most important body movement (stretchability), sensorial (bending rigidity) and thermophysiological comfort (air permeability, water vapour permeability, and thermal resistance) properties of these fabrics were tested and evaluated statistically. The results revealed that high levels of clothing comfort and performance properties can be established by different yarn types and fabric compositions and this will lead to achieve a successful medical therapy.