The relation of adiponectin and tumor necrosis factor a levels between endothelial nitric oxide synthase, angiotensin-converting enzyme, transforming growth factor beta, and tumor necrosis factor a gene polymorphism in adrenal incidentalomas


HARMAN E., KARADENIZ M., BIRAY C. , ZENGI A., ÇETİNKALP Ş. , ÖZGEN A. G. , et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.32, ss.881-888, 2009 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 32 Konu: 11
  • Basım Tarihi: 2009
  • Doi Numarası: 10.3275/6279
  • Dergi Adı: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Sayfa Sayısı: ss.881-888

Özet

Objective: The aim of our study was to demonstrate demographic characteristics, presence of inflammatory markers, distribution of angiotensin-converting enzyme (ACE), tumor necrosis factor (TNF), endothelial nitric oxide synthase (eNOS) genotypes and relations among these parameters in these patients and control subjects. Research design and methods: Study samples were collected from 50 patients with adrenal mass and 30 control groups. The eNOS, ACE, TNF-alpha, transforming growth factor (TGF)-beta genes polymorphisms, TNF-alpha, adiponectin levels were analysed in 50 unrelated Turkish patients with a diagnosis of adrenal incidentaloma (Al). Results: There was statistically significant difference between TNF-alpha levels of patient and controls (p=0.048). We have not detected the connection between TGF-beta, TNF-alpha, ACE, eNOS gene polymorphism with serum TNF-alpha and adiponectin levels. In this study, we demonstrated that there were significant differences for ACE genotypes in the patients when compared to the controls (p<0.05). The percentages of the ID, DID, 11 genotypes for ACE gene polymorphism in the patients group were 30.0, 13.0, 7.0%, respectively. Conclusions: According to different cases of eNOS, TGF-beta, ACE, and TNF-alpha gene genotypes; no statistical significant difference was found between basal cortisol, ACTH, DHEAS, metanephrine, renin, aldosterone, normetanephrine, 17-hydroxyprogesterone, 1 mg low-dose dexamethasone suppression test-cortisol response and Al size. In this study, I/D genotype was determined to be statistically higher in ACE gene in patients with Al (p=0.014). (J. Endocrinol. Invest. 32: 881-888, 2009) (C) 2009, Editrice Kurtis