Investigation of the Adherence and Proliferation Characteristics of SH-SY5Y Neuron Model Cells on Graphene Foam Surfaces

Morcimen Z. G. , Tasdemir S. , Erdem C., Gunes F., ŞENDEMİR A.

15th International Conferences and Exhibition on Nanosciences and Nanotechnologies (NN) / 11th International Symposium on Flexible Organic Electronics (ISFOE), Thessaloniki, Greece, 30 June - 07 July 2018, vol.19, pp.40-46 identifier identifier

  • Publication Type: Conference Paper / Full Text
  • Volume: 19
  • Doi Number: 10.1016/j.matpr.2019.07.654
  • City: Thessaloniki
  • Country: Greece
  • Page Numbers: pp.40-46

Abstract

Graphene is a promising material for production of biocompatible surfaces with suitable physicochemical properties for effective adhesion, proliferation and differentiation of nerve cells. In this study, 3-dimensional (3D) graphene foam was synthesized via chemical vapour deposition method, and it was aimed to observe the effects of graphene foam scaffolds on SH-SY5Y dopaminergic neuron model cells before applying to clinics Raman spectroscopy, XRD and SEM analyses were performed to characterize the graphene foam. Viability of SH-SY5Y cells cultured on graphene foam scaffolds was analysed on days 1, 4 and 7 by MTT. Furthermore, cell morphology was determined by fluorescence staining of the actin cytoskeleton. (C) 2019 Elsevier Ltd. All rights reserved.