Interference in ACTH immunoassay negatively impacts the management of subclinical hypercortisolism


Yener S., Demir L., DEMİRPENCE M., Baris M. M. , Simsir I. , Ozisik S., ...Daha Fazla

ENDOCRINE, cilt.56, ss.308-316, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 56 Konu: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s12020-017-1268-7
  • Dergi Adı: ENDOCRINE
  • Sayfa Sayıları: ss.308-316

Özet

Purpose Low plasma corticotropin is considered a useful parameter for the diagnosis of subclinical hypercortisolism in patients with an adrenal incidentaloma. However, immunoassays are vulnerable to interference from endogenous antibodies. In this study, subjects who underwent Hypothalamus-pituitary-adrenal axis evaluation for the assessment of subclinical hypercortisolism were evaluated. The objective of the study was to ascertain whether antibody interference in corticotropin immunoassay affected the diagnostic work-up and clinical decisions.