Interference in ACTH immunoassay negatively impacts the management of subclinical hypercortisolism

Yener S., Demir L., DEMİRPENCE M., Baris M. M. , Simsir I. , Ozisik S., ...More

ENDOCRINE, vol.56, no.2, pp.308-316, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1007/s12020-017-1268-7
  • Title of Journal : ENDOCRINE
  • Page Numbers: pp.308-316


Purpose Low plasma corticotropin is considered a useful parameter for the diagnosis of subclinical hypercortisolism in patients with an adrenal incidentaloma. However, immunoassays are vulnerable to interference from endogenous antibodies. In this study, subjects who underwent Hypothalamus-pituitary-adrenal axis evaluation for the assessment of subclinical hypercortisolism were evaluated. The objective of the study was to ascertain whether antibody interference in corticotropin immunoassay affected the diagnostic work-up and clinical decisions.