PHARMACEUTICAL BIOLOGY, cilt.44, ss.121-126, 2006 (SCI İndekslerine Giren Dergi)
The aim of the current study was to investigate the protective effects of essential oils, used in traditional Turkish food and medicine, prepared from two Ziziphora subspecies against H2O2 -induced oxidative damage in human erythrocytes. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities, and effects of lipid peroxidation (LPO) and reduced glutathione (GSH) levels of the essential oils on erythrocyte were assessed. The results indicated that both essential oils of Ziziphora species were effective on antioxidant enzyme systems of erythrocytes when compared with H2O2 group. Ziziphora taurica Bieb. subsp. taurica was more effective than endemic Ziziphora taurica Bieb. subsp. cleonioides (Boiss) P. H. Davis on CAT, GPx, and SOD enzyme systems of erythrocytes. In this study, we established that the essential oils of Z. taurica subsp . taurica contained caryophyllene oxide (26.16%), ss-caryophyllene (24.80%), and germacrene-D (7.92%), and Z. taurica subsp . cleonioides contained (+)-pulegone (69.24%), piperitenone (6.47%), and limonene (3.59%). Results presented here may suggest that the essential oils possess antioxidant properties, and therefore they can be used in the nutraceutical or pharmaceutical industry.