Detection and Identification of Old World Leishmania by High Resolution Melt Analysis

Talmi-Frank D., NASEREDDİN A., SCHNUR L. F. , SCHONIAN G., TÖZ S. , JAFFE C., ...Daha Fazla

PLOS NEGLECTED TROPICAL DISEASES, cilt.4, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Background: Three major forms of human disease, cutaneous leishmaniasis, visceral leishmaniasis and mucocutaneous leishmaniasis, are caused by several leishmanial species whose geographic distribution frequently overlaps. These Leishmania species have diverse reservoir hosts, sand fly vectors and transmission patterns. In the Old World, the main parasite species responsible for leishmaniasis are Leishmania infantum, L. donovani, L. tropica, L. aethiopica and L. major. Accurate, rapid and sensitive diagnostic and identification procedures are crucial for the detection of infection and characterization of the causative leishmanial species, in order to provide accurate treatment, precise prognosis and appropriate public health control measures.