Toll-like receptor 2 and 4 gene polymorphisms in generalized aggressive periodontitis


EMINGIL G. , Berdeli A. , BAYLAS H., SAYGAN B. H. , GUERKAN A., KOESE T., ...More

JOURNAL OF PERIODONTOLOGY, vol.78, no.10, pp.1968-1977, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1902/jop.2007.060360
  • Title of Journal : JOURNAL OF PERIODONTOLOGY
  • Page Numbers: pp.1968-1977
  • Keywords: pathogenesis, periodontitis, polymorphism, TLR2, TLR4, TOLL-LIKE RECEPTORS, EARLY-ONSET PERIODONTITIS, INNATE IMMUNE-RESPONSE, SINGLE-NUCLEOTIDE POLYMORPHISMS, TUMOR-NECROSIS-FACTOR, ASSOCIATION, DISEASE, MUTATIONS, TLR4, RISK

Abstract

Background: Toll-like receptors (TLRs) recognize exogenous ligands such as lipopolysaccharide and bacterial lipoprotein during the immune responses to pathogens. The aim of the present study was to investigate whether TLR2 and TLR4 gene polymorphisms are related to susceptibility to generalized aggressive periodontitis (GAgP).