The Regulation of Matrix Metalloproteinase Expression and the Role of Discoidin Domain Receptor 1/2 Signalling in Zoledronate-treated PC3 Cells.


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REEL B. , Korkmaz C. G. , ARUN M. Z. , YILDIRIM G. , ÖĞÜT D., KAYMAK A. , ...More

Journal of Cancer, vol.6, no.10, pp.1020-9, 2015 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.7150/jca.12733
  • Title of Journal : Journal of Cancer
  • Page Numbers: pp.1020-9
  • Keywords: Discoidin domain receptor, MMP, cancer, bisphosphonate, zoledronate, cell culture, NITROGEN-CONTAINING BISPHOSPHONATES, PROSTATE-CANCER, BREAST-CANCER, EXTRACELLULAR-MATRIX, PROTECTIVE ROLE, ACID, INHIBITION, INVASION, ACTIVATION, MIGRATION

Abstract

Discoidin Domain Receptors (DDR1/DDR2) are tyrosine kinase receptors which are activated by collagen. DDR signalling regulates cell migration, proliferation, apoptosis and matrix metalloproteinase (MMP) production. MMPs degrade extracellular matrix (ECM) and play essential role in tumor growth, invasion and metastasis. Nitrogen-containing bisphosphonates (N-BPs) which strongly inhibit osteoclastic activity are commonly used for osteoporosis treatment. They also have MMP inhibitory effect. In this study, we aimed to investigate the effects of zoledronate in PC3 cells and the possible role of DDR signalling and downstream pathways in these inhibitory effects.