In this study aimed at increasing sustainability in soilless cultivation, volcanic tuff was used as substrate and the tested plant material was blocky type pepper (cv. 4-Ever F,). Three experimental factors were evaluated: cultivation system (open or closed), nutrient composition (N-1, N-2, N-3, N-4) and irrigation frequency (I-1, I-2, I-3, I-4). Macro nutrient concentrations of N-2, N-3 and N-4 were 2-, 3- and 4-fold of N-1. Concentrations of micronutrients were the same for all treatments. Irrigation was started when indoor solar radiation reached 6, 4, 2 and 1 MJ m(-2) in the treatments I-1, I-2, I-3 and 14, respectively. As a sustainable soilless technique, closed system was found to be recommendable by incorporating the treatment N-4 + I-2 to provide high yield and quality for blocky type pepper production. In the case of an open system, N-2 + I-4 proved to be the most efficient strategy.