Association of mannose binding lectin codon 54 polymorphism with predisposition to Henoch-Schonlein purpura in childhood

Durmaz B. , AYKUT A. , HURSITOGLU G., BAK M., SERDAROGLU E., ONAY H. , ...Daha Fazla

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, cilt.17, ss.317-320, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/1756-185x.12321
  • Dergi Adı: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
  • Sayfa Sayıları: ss.317-320

Özet

AimImmune and inflammatory response activation is a common feature of systemic vasculitis. There is a protein called mannose binding lectin (MBL) that was reported to play an important role in innate immunity. MBL polymorphisms in the MBL gene cause predisposition to infectious and autoimmune diseases. There is no study in the literature investigating the association between MBL polymorphisms and Henoch-Schonlein purpura (HSP) to date. Therefore, the aim of this study is to determine the presence of any association between MBL gene variants and HSP in a child population.