This paper describes the regulation of the body temperature using an agent-based control system which can be used to simulate and visualize the process of homeostatic control systems inside the human body. The goal is to observe and analyze model dynamics on the negative feedback control mechanism with the agent-based modeling approach of the intelligent system. Agent-based modeling and simulation is a computational modeling which offers researchers to solve complex and practical problems using algorithmic descriptions. In this study, we present the concepts and illustrate graphically how the thermoregulatory system achieves balance between heat production or heat loss. It considers that the control system developed with a different modeling approach could be a case study for learning, for researching and for exploring into other human homeostatic control system.