Inflammation-Induced Thrombosis: Mechanisms, Disease Associations and Management


AKSU K. , DÖNMEZ A. , KESER G.

CURRENT PHARMACEUTICAL DESIGN, cilt.18, ss.1478-1493, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 18 Konu: 11
  • Basım Tarihi: 2012
  • Dergi Adı: CURRENT PHARMACEUTICAL DESIGN
  • Sayfa Sayıları: ss.1478-1493

Özet

Although inflammation-induced thrombosis is a well-known entity, its pathogenesis remains complicated. There are complex interactions between inflammation and hemostasis, involving proinflammatory cytokines, chemokines, adhesion molecules, tissue factor expression, platelet and endothelial activation, and microparticles. Inflammation increases procoagulant factors, and also inhibits natural anticoagulant pathways and fibrinolytic activity, causing a thrombotic tendency. Besides, chronic inflammation may cause endothelial damage, resulting in the loss of physiologic anticoagulant, antiaggregant and vasodilatory properties of endothelium. However, inflammation-induced venous thrombosis may develop even in the absence of vessel wall damage. On the other hand, coagulation also augments inflammation, causing a vicious cycle. This is mainly achieved by means of thrombin-induced secretion of proinflammatory cytokines and growth factors. Platelets may also trigger inflammation by activating the dendritic cells.