Investigation of the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis


Shademan B., Nourazarian A., Nikanfar M., BİRAY AVCI Ç. , Hasanpour M., Isazadeh A.

JOURNAL OF CLINICAL NEUROSCIENCE, vol.78, pp.189-193, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jocn.2020.04.071
  • Title of Journal : JOURNAL OF CLINICAL NEUROSCIENCE
  • Page Numbers: pp.189-193

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease and the most common neurodegenerative status. MicroRNAs play an important role in macrophage response to inflammatory processes, and alterations in miRNA levels trigger the inactivation of specific T lymphocytes. As a result, these factors can lead to autoimmune diseases such as MS. Therefore, to determine the role of MicroRNA-146a and MicroRNA-155 in MS patients, their expression levels in serum of MS patients were compared with healthy controls.