Investigation of the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis


Shademan B., Nourazarian A., Nikanfar M., BİRAY AVCI Ç. , Hasanpour M., Isazadeh A.

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.78, ss.189-193, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 78
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jocn.2020.04.071
  • Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
  • Sayfa Sayıları: ss.189-193

Özet

Multiple sclerosis (MS) is a chronic inflammatory disease and the most common neurodegenerative status. MicroRNAs play an important role in macrophage response to inflammatory processes, and alterations in miRNA levels trigger the inactivation of specific T lymphocytes. As a result, these factors can lead to autoimmune diseases such as MS. Therefore, to determine the role of MicroRNA-146a and MicroRNA-155 in MS patients, their expression levels in serum of MS patients were compared with healthy controls.