A diagnostic tool for population models using non-compartmental analysis: The ncappc package for R


Acharya C., Hookers A. C. , Turkyilmaz G. , Jonsson S., Karlsson M. O.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, cilt.127, ss.83-93, 2016 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 127
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.cmpb.2016.01.013
  • Dergi Adı: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
  • Sayfa Sayısı: ss.83-93

Özet

Background and objective: Non-compartmental analysis (NCA) calculates pharmacokinetic (PK) metrics related to the systemic exposure to a drug following administration, e.g. area under the concentration time curve and peak concentration. We developed a new package in R, called ncappc, to perform (i) a NCA and (ii) simulation-based posterior predictive checks (ppc) for a population PK (PopPK) model using NCA metrics.