Wrinkle is an undesirable effect for the shirt fabrics, which occurs during usage. There are various finishing materials and treatment methods to give fabrics crease resistance property. In this study, we conducted an experiment to evaluate effect of wrinkle resistance finish on wrinkle recovery, tensile, pilling and drape properties of shirt fabrics produced from 100% cotton fabrics. For this purpose, fabrics in plain and sateen constructions were woven using by No 50/1 cotton yarns and later, wrinkle resistance finishing was applied. Afterwards, the treated fabrics were tested for their physical properties. A statistical analysis using independent samples t-test with the significance level of alpha = 0.05 has been performed to determine if a statistically significant difference exists among test results. In conclusion, crease resistance finishing seems to have an increasing effect on wrinkle recovery angle (WRA) and pilling tendency, whereas it leads to a decrease in drape angle (drapeability), breaking and tearing resistance of the fabrics.