The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis


Colak D. G. , Cianga I., Demirkol D. O. , Kozgus O., Medine E. I. , Sakarya S., ...Daha Fazla

JOURNAL OF MATERIALS CHEMISTRY, cilt.22, ss.9293-9300, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 22 Konu: 18
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1039/c2jm30692a
  • Dergi Adı: JOURNAL OF MATERIALS CHEMISTRY
  • Sayfa Sayıları: ss.9293-9300

Özet

Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via I-125 which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.