Effects of rapamycin and AZD3463 combination on apoptosis, autophagy, and cell cycle for resistance control in breast cancer

ÖZATEŞ AY N. P. , Sogutlu F., Lerminoglu F., DEMİR ÇETİNKAYA B. , GÜNDÜZ C. , Shademan B., ...More

LIFE SCIENCES, vol.264, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 264
  • Publication Date: 2021
  • Doi Number: 10.1016/j.lfs.2020.118643
  • Title of Journal : LIFE SCIENCES


Breast cancer is the most common cancer in women and the leading cause of cancer mortality in women over 40 it's the year. The existence of the PI3K/AKT/mTOR pathway aberrations in more than 70% of breast cancer has caused to become a therapeutic target. AZD3463 is an anti-cancer agent used as a potential inhibitor of ALK/IGF1R. It also induces apoptosis and autophagy of the PI3K/AKT/mTOR pathway in cancer cells. Although the mTOR signaling might be inhibited by rapamycin treatment, signals transmitted from the upstream pathway supports cell survival and proliferation.