Regression of Endometrial Implants by Resveratrol in an Experimentally Induced Endometriosis Model in Rats


ERGENOĞLU A. M. , YENİEL A. Ö. , ERBAS O., AKTUĞ H. , YILDIRIM N. , ULUKUŞ M. , ...More

REPRODUCTIVE SCIENCES, vol.20, no.10, pp.1230-1236, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 10
  • Publication Date: 2013
  • Doi Number: 10.1177/1933719113483014
  • Title of Journal : REPRODUCTIVE SCIENCES
  • Page Numbers: pp.1230-1236
  • Keywords: resveratrol, endometriosis, cytokines, VEGF, MCP-1, TNF-alpha, ENDOTHELIAL GROWTH-FACTOR, NF-KAPPA-B, MONOCYTE CHEMOTACTIC PROTEIN-1, PERITONEAL ENVIRONMENT, WOMEN, EXPRESSION, DISEASE, CELLS, INTERLEUKIN-6, ANGIOGENESIS

Abstract

Objective: To evaluate the effect of resveratrol on an experimentally induced enometriosis rat model. Study design: After endometriotic implants were surgically formed, rats were randomly divided into 2 groups as control group (saline treated, n = 6) and resveratrol group (10 mg/kg/d, n = 6). The inflammatory markers and histopathological changes were assessed at the end of the treatment period. Results: Our results showed (1) significant reduction in the implant size (P < .0005); (2) significantly decreased levels of vascular endothelial growth factor (VEGF) in the peritoneal fluid and plasma (P < .005); and monocyte chemotactic protein 1 (MCP-1) in the peritoneal fluid (P < .05), (3) highly significant suppression of VEGF expression in the endometriotic tissue (P < .0005); and (4) considerable histological changes in the endometriotic foci following resveratrol treatment. Conclusion: Resveratrol appears to be effective on the development of endometriosis through its antiangiogenic and anti-inflammatory properties. Future studies with different doses of resveratrol might provide more comprehensive results regarding the treatment of endometriosis.