Docetaxel loaded human serum albumin nanoparticles; synthesis, characterization, and potential of nuclear imaging of prostate cancer


Ertugen E., Tuncel A., Yurt F.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol.55, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jddst.2019.101410
  • Title of Journal : JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Abstract

In this study, docetaxel loaded nanoparticles were synthesized and labeled with I-131 for diagnosis and treatment of prostate cancer. Docetaxel (DTX) was loaded onto human serum albumin nanoparticles (HSA) with 50% efficiency. The size of DTX loaded nanoparticles (DTX-HSA) is in the range of 150-160 nm and these nanoparticles have a zeta potential of - 27.2 mV. In in vitro drug release assay, 80% of DTX from loaded DTX-HSA nanoparticles was released at pH 7.4 medium, while 93% of DTX was released from DTX-HSA nanoparticles at pH 5.8 medium at the end of 48 h. The data show that HSA nanoparticles might be increasing in chemotherapy effect as a drug delivery system.