A Src/Abl kinase inhibitor, bosutinib, downregulates and inhibits PARP enzyme and sensitizes cells to the DNA damaging agents


Kirmizibayrak P. , İLHAN R. , Yilmaz S. , GUNAL S., Tepedelen B. E.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.43, ss.101-109, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 43 Konu: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1515/tjb-2017-0095
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.101-109

Özet

Background: Poly(ADP-ribosyl)ation (PARylation) catalyzed mainly by PARP1 is a highly regulated posttranslational modification associated with several pathways in cellular physiology and genotoxic deoxyribonucleic acid (DNA) damage response. PAR polymers and PARP enzyme function in DNA integrity maintenance and several PARP inhibitors have entered clinical phase studies for cancer therapies.