Carbamylated low-density lipoprotein induces death of endothelial cells: A link to atherosclerosis in patients with kidney disease

Ok E. , Basnakian A., Apostolov E., Barri Y., Shah S.

KIDNEY INTERNATIONAL, vol.68, no.1, pp.173-178, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1523-1755.2005.00391.x
  • Title of Journal : KIDNEY INTERNATIONAL
  • Page Numbers: pp.173-178

Abstract

Background. The presence of accelerated atherosclerosis in patients with kidney disease cannot be entirely explained by traditional cardiovascular risk factors. Exposure to urea, which is normally present in human blood plasma and elevated in patients with kidney disease, leads to the carbamylation of proteins. We postulated that low-density lipoprotein (LDL) carbamylated by urea has biologic effects relevant to atherosclerosis.