Multifunctional molecular imaging probes for estrogen receptors: Tc-99m labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)


Moharrami P., Unak P. , Guldu O. K. , Medine E. I. , Gumuser G., Bilgin E. S. , et al.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.314, ss.2609-2620, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 314 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s10967-017-5630-2
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayısı: ss.2609-2620

Özet

A theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with Tc-99m which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of Tc-99m-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that Tc-99m-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies.