In vivo biological evaluation of I-131 radiolabeled-paclitaxel glucuronide (I-131-PAC-G)


Aslan O., Muftuler F. Z. B. , Kilcar A. Y. , Ichedef C. , Unak P.

RADIOCHIMICA ACTA, cilt.100, ss.339-345, 2012 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 100 Konu: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1524/ract.2012.1922
  • Dergi Adı: RADIOCHIMICA ACTA
  • Sayfa Sayısı: ss.339-345

Özet

Paclitaxel (PAC) is a natural occurring diterpene alkoloid originally isolated from the bark of Taxus Brevifolia. It is one of the most important antitumor agents for clinical treatment of ovarian, breast non-small cell lung and prostate cancers. It is known that these types of cancer cells have high beta-glucuronides enzyme which can catalyze the hydrolysis of glucuronides. This is why the synthesis compounds which undergo glucuronidation come into question in the imaging and therapy of these cancer cells.