Prevention of Pazopanib-Induced Prolonged Cardiac Repolarization and Proarrhythmic Effects


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Akman T., ERBAŞ O. , AKMAN L. , YILMAZ A. U.

ARQUIVOS BRASILEIROS DE CARDIOLOGIA, vol.103, no.5, pp.403-409, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.5935/abc.20140138
  • Title of Journal : ARQUIVOS BRASILEIROS DE CARDIOLOGIA
  • Page Numbers: pp.403-409

Abstract

Background: Pazopanib (PZP) may induce prolonged cardiac repolarization and proarrhythmic effects, similarly to other tyrosine kinase inhibitors. Objectives: To demonstrate PZP-induced prolonged cardiac repolarization and proarrhythmic electrophysiological effects and to investigate possible preventive effects of metoprolol and diltiazem on ECG changes (prolonged QT) in an experimental rat model.