Prevention of Pazopanib-Induced Prolonged Cardiac Repolarization and Proarrhythmic Effects


Creative Commons License

Akman T., ERBAŞ O. , AKMAN L. , YILMAZ A. U.

ARQUIVOS BRASILEIROS DE CARDIOLOGIA, cilt.103, ss.403-409, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 103 Konu: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5935/abc.20140138
  • Dergi Adı: ARQUIVOS BRASILEIROS DE CARDIOLOGIA
  • Sayfa Sayıları: ss.403-409

Özet

Background: Pazopanib (PZP) may induce prolonged cardiac repolarization and proarrhythmic effects, similarly to other tyrosine kinase inhibitors. Objectives: To demonstrate PZP-induced prolonged cardiac repolarization and proarrhythmic electrophysiological effects and to investigate possible preventive effects of metoprolol and diltiazem on ECG changes (prolonged QT) in an experimental rat model.