Telomerase inhibition regulates EMT mechanism in breast cancer stem cells


Kusoglu A., Bagca B. , Ay N. P. , Gunduz C. , Avci C.

GENE, vol.759, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 759
  • Publication Date: 2020
  • Doi Number: 10.1016/j.gene.2020.145001
  • Title of Journal : GENE

Abstract

Backround: CSCs having the common features of high telomerase activity and high migration and invasion capabilities play a vital role as the initiators of metastasis. Small molecule BIBR1532 has been shown to target cancer cells by inhibiting telomerase. Recent studies have suggested that telomerase activity is associated with epithelial mesenchymal transition (EMT). EMT program, which causes epithelial cells to acquire a mesenchymal morphology, is known to play a significant role in cancer metastasis.