Investigation of the Adherence and Proliferation Characteristics of SH-SY5Y Neuron Model Cells on Graphene Foam Surfaces


Morçimen Z., Taşdemir Ş., Erdem Ç., Güneş F., Şendemir A.

Materials Today: Proceedings, vol.19, no.1, pp.40-46, 2019 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2019
  • Title of Journal : Materials Today: Proceedings
  • Page Numbers: pp.40-46

Abstract

Graphene is a promising material for production of biocompatible surfaces with suitable physicochemical properties for effective adhesion, proliferation and differentiation of nerve cells. In this study, 3-dimensional (3D) graphene foam was synthesized via chemical vapour deposition method, and it was aimed to observe the effects of graphene foam scaffolds on SH-SY5Y dopaminergic neuron model cells before applying to clinics. Raman spectroscopy, XRD and SEM analyses were performed to characterize the graphene foam. Viability of SH-SY5Y cells cultured on graphene foam scaffolds was analysed on days 1, 4 and 7 by MTT. Furthermore, cell morphology was determined by fluorescence staining of the actin cytoskeleton.