The Disappearing Brain-Sparing Effect in Early-Onset Fetal Growth Restriction Fetuses Revisited


YENİEL A. Ö. , ERGENOĞLU A. M. , SANHAL C. Y. , AKDEMİR A. , AKERCAN F. , KAZANDI M. , ...More

FETAL DIAGNOSIS AND THERAPY, vol.36, no.2, pp.166-172, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1159/000355933
  • Title of Journal : FETAL DIAGNOSIS AND THERAPY
  • Page Numbers: pp.166-172

Abstract

Objective: To evaluate the association between the brain-sparing situation and perinatal outcomes in fetuses with early-onset fetal growth restriction (EO-FGR) with absent or reverse end-diastolic flow in the umbilical artery (UA A/REDF). Methods: We evaluated fetuses with EO-FGR who had patterns of UA A/REDF without abnormal venous Doppler indices. Participants were divided into two groups according to measurements of mid-cerebral artery pulsatility index (MCA PI) just before delivery. Group 1 (n = 45) included those with a brain-sparing effect (BSE) (a MCA PI <5th percentile for the gestational age) and group 2 (n = 14) included those with a disappearing BSE, defined as an MCA PI increase towards normal values after the BSE detected at the initial evaluation. Short-term perinatal outcomes were analyzed. Results: Compared to group 1, group 2 had a significantly low birth weight (p = 0.018) and high rates of extended neonatal intensive care unit hospitalization (p = 0.049 respectively). Conclusion: On the basis of longitudinal measurements of MCA PI, increases after the reduction <5th percentile might be related to poor perinatal outcomes in fetuses with EO-FGR who had UA A/REDF without abnormal venous flow patterns. (C) 2013 S. Karger AG, Basel