Correlation between telomerase and mTOR pathway in cancer stem cells

DOGAN F., Avci C. B.

GENE, vol.641, pp.235-239, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 641
  • Publication Date: 2018
  • Doi Number: 10.1016/j.gene.2017.09.072
  • Title of Journal : GENE
  • Page Numbers: pp.235-239


Cancer stem cells (CSCs), which are defined as a subset of tumor cells, are able to self -renew, proliferate, differentiate similar to normal stem cells. Therefore, targeting CSCs has been considered as a new approach in cancer therapy. The mammalian target of rapamycin (mTOR) is a receptor tyrosine kinase which plays an important role in regulating cell proliferation, differentiation, cell growth, self-renewal in CSCs.