Correlation between telomerase and mTOR pathway in cancer stem cells


DOGAN F., Avci C. B.

GENE, cilt.641, ss.235-239, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Cancer stem cells (CSCs), which are defined as a subset of tumor cells, are able to self -renew, proliferate, differentiate similar to normal stem cells. Therefore, targeting CSCs has been considered as a new approach in cancer therapy. The mammalian target of rapamycin (mTOR) is a receptor tyrosine kinase which plays an important role in regulating cell proliferation, differentiation, cell growth, self-renewal in CSCs.