Nitric oxide contributes to the spinal nociceptive processing

Maiskii V., Kayalioglu G. , Govsa F., Erdem B., Hariri N.

NEUROPHYSIOLOGY, cilt.30, ss.370-374, 1998 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 30 Konu: 6
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1007/bf03027681
  • Sayfa Sayıları: ss.370-374


NADPH-diaphorase-containing neurons (it is supposed that this enzyme is a form of NO-synthase, NOS) were histochemically identified in the spinal cord of rats. in another set of the experiments, we identified neurons sources of spinothalamic and spinomesencaphalic pathways - by their retrograde labelling with Fluoro-Gold (FG) Injected into the thalamus and periaqueductal gray substance. It was shown that NOS-containing spinal cells are, as a rule, propriospinal intersegmental or intrasegmental interneurons. We discuss the possible involvement of these cells in the "inhibition-of-inhibition" processes and in potentiation of the synaptic transmission in spinal neurons under conditions of the development of tonic or chronic pain. In rats, the number of NOS-containing neurons, which are also retrogradely labelled with FG after dye injection into the thalamus and midbrain, is rather limited.