Prevalence of the Angiotensin I Converting Enzyme Gene Insertion/Deletion Polymorphism in a Healthy Turkish Population


BERDELİ A. , Cam F. S.

BIOCHEMICAL GENETICS, vol.47, pp.412-420, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47
  • Publication Date: 2009
  • Doi Number: 10.1007/s10528-009-9240-8
  • Title of Journal : BIOCHEMICAL GENETICS
  • Page Numbers: pp.412-420
  • Keywords: ACE I/D, Allele, Frequency, Healthy volunteers, Turkish, CORONARY HEART-DISEASE, DELETION POLYMORPHISM, RISK-FACTOR, CARDIOVASCULAR-DISEASE, DIABETES-MELLITUS, I/D POLYMORPHISM, BLOOD-PRESSURE, D-ALLELE, ACE, HYPERTENSION

Abstract

Angiotensin converting enzyme (ACE) plays an essential role in the renin-angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations.