In vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica


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Can H. , Kayalar H. , Bozkurt B. , Can S., Döşkaya M. , Töz S.

ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.65, ss.373-377, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 65
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1501/vetfak_0000002870
  • Dergi Adı: ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Sayfa Sayısı: ss.373-377

Özet

Complex clinical symptoms such as ulcerative skin lesions, destructive mucosal inflammation, and disseminated visceral infection can reveal in leishmaniasis. The conventional drugs are toxic and expensive. In addition, patients receive a long treatment with these drugs which have adverse effects and unfortunately there are some limitations during the treatment. The aim of this study is to investigate the in vitro anti-leishmanial activities of four different extracts of Sarcopoterium spinosum against Leishmania tropica. Initially, different concentrations of ethanol, methanol, n-hexane, and water extracts of S. spinosum were incubated with L. tropica promastigotes. After 72 hours of incubation, the growth of L. tropica promastigotes was significantly inhibited and the percentage of inhibition ranged between 42.8 and 100 %. Among these extracts, the most efficient growth inhibition (100 %) was obtained with methanol extract (at a dose of 50 mu g/ml). In conclusion, S. spinosum may be a potential source for the development of novel therapeutic agents to treat L. tropica infection.